Five female filmmakers en route to screen their new horror film in Los Angeles, experience their own real life terror when they cross paths with deranged scientist hellbent on using them for his twisted experiments.
Dr Simon Helder, sentenced to an insane asylum for crimes against humanity, recognises its director as the brilliant Baron Frankenstein, the man whose work he had been trying to emulate before his imprisonment. Frankenstein utilises Helder's medical knowledge for a project he has been working on for some time. He is assembling a man from vital organs extracted from various inmates in the asylum. And the Baron will resort to murder to acquire the perfect specimens for his most ambitious project ever.
Cocky researcher Sebastian Caine is working on a project to make living creatures invisible. Determined to achieve the ultimate breakthrough, Caine pushes his team to move to the next phase — using himself as the subject. The test is a success, but when the process can't be reversed and Caine seems doomed to future without flesh, he starts to turn increasingly dangerous.
Held captive in a futuristic smart house, a woman hopes to escape by befriending the A.I. program that controls the house.
A wisecracking New York reporter intrudes on a research scientist's quest to unmask The Moon Killer.
Mad scientist turns a man into an electrically-controlled monster to do his bidding.
Amanda's deathbed request to her son, John, was for him to destroy all the lab notes etc. from her last experiment. She also blurts out he had a brother. At the funeral John meets Melissa, who claims to be his mother's biggest fan. Together with some of John's friends they go to Amanda's house, but none are prepared for what they find there.
A woman wakes up injured in a basement surrounded by corpses. To survive, she pretends to be dead while a grotesque ritual unfolds in the house above.
Rescued from the guillotine by his devoted dwarf Fritz, the Baron relocates to Carlsbruck, where he continues his gruesome experiments.
In the early 1970s, Dr. Henry West creates an institute to find people with supernatural abilities. When Judith Winstead comes to the facility, she exhibits amazing abilities that the military wants to turn into a weapon.
When Seth Brundle makes a huge scientific and technological breakthrough in teleportation, he decides to test it on himself. Unbeknownst to him, a common housefly manages to get inside the device and the two become one.
A boy named Eli with a rare autoimmune disorder is confined to a special experimental clinic for his treatment. He soon begins experiencing supernatural forces, turning the supposedly safe facility into a haunted prison for him and his fellow patients.
A deformed tormented girl drowns herself after her lover is framed for murder and guillotined. Baron Frankenstein, experimenting with the transfer of souls, places the boy's soul into her body, bringing Christina back to life. Driven by revenge, she carries out a violent retribution on those responsible for both deaths.
Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
When researchers rescue a fellow scientist who survived a meteorite strike in the Arctic, they discover she may not be who they think she is. Is she some-how changed?
After losing his wife and his memory in a car accident, a single father undergoes an experimental treatment that causes him to question who he really is.
A biologist signs up for a dangerous, secret expedition into a mysterious zone where the laws of nature don't apply.
Crazed members of a sadistic family return to their childhood home to terrorize the new owners.
A severely injured man and woman awake in an abandoned sanitarium only to discover that a sadistic caretaker holds the keys to their freedom and the horrific answers as to their true identity.
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